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Arthritis & Other Common Causes of Joint Pain

 

GENERAL INFORMATION

Many orthopedic problems involve the joints, as joints serve as the junction between your body’s bones and involve many tendons, muscles, and ligaments.  Joints allow us to bend and straighten our bodies in order to perform coordinated movements.  They also adjust during movements to give us leverage and bear the loads as we move.  Similar structures make up almost all the joints in our bodies.

  

Many conditions can cause joint pain.  Several common causes found in an orthopedic setting are described below.

 

RHEUMATOID ARTHRITIS

Rheumatoid arthritis is a chronic inflammation of the fluid membranes that surround the joints in the body.  Over time, the inflammation causes erosion of cartilage and bone in an affected joint as well as damage to supporting structures like ligaments and tendons.  The exact cause of rheumatoid arthritis, such as it being related to a virus or bacteria, is not known, but it is known that it is an autoimmune process.  This means that the body reacts to its own defenses in a negative way that leads to a further destruction and progression of the disorder.

 

Anyone can have rheumatoid arthritis, although it is often seen in families, women of child-bearing years, and Native Americans.  The joints in the fingers, feet, wrists, knees, elbows, and ankles are most commonly affected.  Though there are many forms of rheumatoid, it is a condition that usually starts without warning with joint pain over a couple of months.  The initial joints that are affected remain a problem while the condition progresses to other joints in a symmetrical fashion.  It is common to experience flares and exacerbations with periods of remissions.

 

Rheumatoid arthritis causes swelling, warmth, and tenderness in the joints or sheaths surrounding the tendons, sometimes referred to as “marshmallow joints”.  Nodules or deformities can frequently develop.  Stiffness is common in the morning and after increased activity and use.  In addition, rheumatoid might cause general weakness, fatigue, weight loss, or low fever.   

 

Diagnosis of rheumatoid arthritis involves a careful history and physical examination.  X-rays may be taken of problematic joints to look for signs of rheumatoid, such as narrowed joint spaces, erosions at the margins of joints, signs of demineralization around the joints, or fusion of joints from uncontrolled inflammation.  Joints may be aspirated to evaluate the joint fluid for rheumatoid or other suspected causes of inflammation.  Laboratory tests that can sometimes be helpful in diagnosing the disorder might be performed if more evidence is needed to confirm the diagnosis of rheumatoid.

 

Treatment of rheumatoid arthritis involves lifestyle modifications of pacing activities with rest and maintaining a balanced diet.  Physical therapy may be recommended to help maintain motion and strength.  In addition, there are many medications that can be used to treat rheumatoid.  These might include one or a combination of anti-inflammatory medications, steroids, or disease modifying anti-rheumatoid drugs (called “DMARDs”) which work to slow the disease progression.  A newer category of medication called "biologics" aim at fighting the actual autoimmune process itself.  

 

OSTEO-ARTHRITIS

Osteo-arthritis is the most common cause for chronic joint pain in the United States.  It is a “wear-and-tear” process that involves progressive degeneration of the cartilage that lines our joints that articulate with each other.  When this process is started, it leads to subsequent damage to underlying bone and reactive formation of new bone at the margins of the cartilage.  Because of the nature of the process, osteo-arthritis usually affects people in their fifties or older (with a predominance for women greater than men in this age group), but may be accelerated by trauma or past injuries involving a joint (called “post-traumatic arthritis”). 

 

The symptoms of osteo-arthritis progress from occasional to more and more frequent over a period of time.  A cracking or gritty sensation may be present with movement of the affected joint, and overuse may aggravate the discomfort, leading to limited motion.  Swelling, increased fluid in the joints, morning stiffness, and sometimes deformity in the joints are also common.  Unlike rheumatoid arthritis, osteo-arthritis may only involve one joint or it may involve multiple joints, and not necessarily symmetrically.  Systemic symptoms such as fever are not involved.  Osteo-arthritis most frequently affects joints in the knees, hips, shoulders, spine, wrists & hands, or previously injured joints.  

 

Diagnosis of osteo-arthritis involves a careful history and physical examination.  X-rays of affected joints might show common signs of osteo-arthritis such as bone spurs (called “osteophytes”), sclerosis, cysts, and narrowed joint spaces from lost cartilage.  Laboratory tests to test for generalized inflammation or to test the composition of joint fluid might be performed to determine if there might be a different cause for joint pain.

 

It is impossible to predict how quickly or to what extent osteo-arthritis will progress in every individual.  There are many options for treatment of osteo-arthritis, and methods selected should be based on both a patient’s functional impairment and quality of life as well as objective evaluation of the extent of the process.  It can not be overstated the importance of weight reduction in overweight individuals in reducing the loads on joints and slowing the progression and symptoms of osteo-arthritis.  Your physician might recommend conservative methods of treatment such as anti-inflammatory medications or glucosamine / chondroiten supplements, and/ or physical or occupational therapy.  Cortisone injections are commonly used to settle the pain caused by inflammation if your arthritis is in the earlier stages.  Visco-suppementation injections (e.g. Synvisc injections) are another option for early but troublesome arthritis to lubricate the joints. 

 

If your arthritis is severe or does not respond to conservative methods of treatment, there are several surgeries that might be recommended.  Arthroscopy surgery in the joint can sometimes be used to smooth out worn, rough cartilage for a period of time to avoid more extensive procedures.  More definitive surgical options are arthrodesis (or fusion) of the arthritic joint.  This is not as commonly done because of the restricted motion that results, but might be considered for certain patients.  Total joint replacement is a very effective and definitive option for those patients who have severe arthritis and who want to retain a relatively normal level of activity and ability.

 

GOUT

Gout is an inflammatory reaction to the accumulation of a certain type of crystals in one or more joints.  The presence of these crystals is the result of a lack of an enzyme that is required to metabolize the compound uric acid in the body.  In gouty arthritis, uric acid is either over-produced or unable to be removed properly from the body’s kidneys.  Disorders that cause over production of uric acid include inherited or congenital defects, bone marrow disorders, or diets high in uric acid (red meats and wine, anchovies, alcohol).  Disorders that hinder the removal of uric acid from the body are usually related to improper functioning of the kidneys, as with kidney failure or certain medications that have effects on the kidneys. 

 

Gout can be an acute or chronic problem.  Gout is rarely seen in persons under thirty years old; rather, first episodes are usually seen in post-menopausal women or men in their fifties.  Injury, surgery, fasting, or excessive food or alcohol intake can trigger attacks.  Early episodes are usually limited to one joint, especially the big toe, whereas a history of multiple attacks might involve more and more joints. Ankles, heels, knees, wrists, fingers, and elbows are the most commonly affected joints. Attacks might last days up to weeks, getting more frequent and severe with lasting symptoms as the chronic condition develops.  Affected joints are very painful, red and swollen, tender to touch, and produce stiffness and limited motion.  Fever is not uncommon with gout, and other systemic problems with the kidneys may result.  As gout progresses to a chronic condition, the swelling becomes more permanent, and the presence of visible nodular masses called "tophi" in pressure points is common.   

 

The diagnosis of gout is made with a careful history and physical examination.  Confirmation of the diagnosis can be made by one or more laboratory tests including analysis of joint fluid, urinalysis, and/ or possibly blood tests.  X-rays or other diagnostic tests might performed to rule out other causes of joint pain, but may only show signs of gout in its chronic stages.

 

Acute attacks of gout usually resolve on their own in one to three weeks.  Anti-inflammatory medications are often a mainstay in the treatment of attacks, as well as other medications that might decrease the production of uric acid in the body or increase its removal.  If gouty arthritic attacks affect multiple joints and/ or are resistant to treatment with anti-inflammatory or steroid medication may be recommended that can help prevent the triggering of future attacks.  

 

INFECTED (SEPTIC) JOINT

Infected joints are an unwanted orthopedic problem.  Infected joints occur when harmful bacteria enter the joints and cause an inflammatory reaction that can lead to damage in the bone, cartilage, tendons, and ligaments.  This can occur from a variety of sources.  Bacteria can be introduced to a joint through:

-          Blunt trauma

-          Spread of existing infections in the bone or soft tissues (muscles, tendons, fat)

-          Spread of existing wound infections

-          Spread of existing infections in another part of the body that spreads through the blood (examples are infections in the urinary tract or lungs)

-          Surgery

-          Infected artificial prosthesis

 

Several bacteria are considered harmful if they overwhelm a joint.  The most common bacteria that cause joint infections usually limit themselves to one joint, such as the knee or hip.  However, other bacteria might cause joint pains that migrate around the body.  Tendons also become inflamed leading to decrease in motion.  Infections cause intense pain, redness, swelling, warmth and tenderness.  There may be purulent drainage from an open wound, or the joint may be puffy and fluctuant. Depending on the bacteria involved, a rash might be present on the extremities or whole body.  Fever is almost always present.

 

Diagnosis of an infected joint involves a careful history and physical examination.  To confirm an infection, the joint is often aspirated for analysis of the fluid.  In addition, laboratory tests of your blood or urine might be considered to determine the source or scope of a possible infection.  X-rays might be taken, especially if an injury was involved. 

 

Almost all people with infected joints are treated in the hospital.  Antibiotics will likely be given through an intravenous line (an “IV”).  Other additional methods of management might include surgery to openly drain, irrigate, or debride the affected area.  Infected joints are usually kept immobilized while being treated.  Antibiotics are often continued taken orally even when you leave the hospital.   

 


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